Microglia: Ally and Enemy in Deep Space

Kira D.A. Rienecker,Maria Serena Paladini,Katherine Grue,Karen Krukowski,Susanna Rosi

Neuroscience & Biobehavioral Reviews（2021）

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摘要

•Resting microglia survey the brain and maintain homeostasis.•Simulated Galactic Cosmic Ray (GCR) exposure triggers chronic microglia activation.•GCR-exposure results in altered synaptic and cognitive functions.•GCR exposure results in sex dimorphic features.•Microglia depletion and repopulation in male mice prevents GCR effects.

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关键词

Microglia,Galactic cosmic rays,Sex dimorphism,Cognition,CNS,Synapses

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