Risk factors and mechanisms of in vivo emergence of colistin resistance in carbapenem-resistant Klebsiella pneumoniae

Po-Han Huang,Yi-Hsiang Cheng, Wen-Yin Chen,Chih-Han Juan,Sheng-Hua Chou,Jin-Town Wang,Chien Chuang,Fu-Der Wang,Yi-Tsung Lin

International Journal of Antimicrobial Agents（2021）

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摘要

•Risk factors for in vivo emergence of colistin resistance in carbapenem-resistant K. pneumoniae (CRKP) were studied.•Colistin exposure is the only independent risk factor for in vivo emergence of colistin resistance in CRKP.•Alteration in mgrB was the predominant mechanism for in vivo emergence of colistin resistance in CRKP.•Mechanisms of colistin resistance in some CRKP strains remained undiscovered.

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关键词

Colistin,Resistance mechanism,Risk factors,Carbapenem,Klebsiella pneumoniae

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