FGF21 alleviates chronic inflammatory injury in the aging process through modulating polarization of macrophages

Kai Kang, Anran Xia,Fanrui Meng,Jian Chunyu,Xu Sun,Guiping Ren,Dan Yu,Xinghao Jiang, Lei Tang,Wei Xiao,Deshan Li

International Immunopharmacology（2021）

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摘要

•FGF21 alleviates the senescence injury and maintains the homeostasis.•FGF21 maintains the homeostasis by inhibiting inflammation and oxidant stress.•FGF21 reduces inflammation and oxidation by regulating macrophages polarization.•FGF21 regulates polarization of macrophages through the AMPKα/NF-κB pathway.

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关键词

FGF21,Senescence,SASP,Oxidant stress,Macrophage phenotype

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