Radiation-Associated Sarcomas: An Update on Clinical, Histologic, and Molecular Features
Surgical Pathology Clinics(2019)
摘要
Approximately half of all cancer patients receive radiation therapy as part of their oncologic treatment. Radiation-associated sarcomas occur in fewer than 1% of patients who receive radiation therapy but account for up to 5% of all sarcomas. As the use of radiation has increased in the past few decades and overall oncologic outcomes are improving, the incidence of radiation-associated sarcomas is also expected to increase. Historically, radiation-associated sarcomas have been associated with poor outcomes but recent data suggest the prognosis is improving. Distinguishing the sarcoma from the primary malignancy is a major diagnostic criterion.
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关键词
Soft tissue,Tumor,Sarcoma,Secondary malignancy,Radiation,Radiation-associated,Immunohistochemistry,Molecular genetics
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