Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models: Implications for model selection and tiered modeling frameworks
Environment International(2021)
摘要
•Study provides explicit guidance on model selection for key exposure scenarios.•Simple toxicokinetic models can be applied to simulate exposure in many cases.•More resolved models are needed to simulate rapidly biotransformed chemicals.•In vitro biotransformation data are useful for assessments but uncertainty remains.
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关键词
Chemical assessment,Toxicokinetics,Biotransformation,Modeling
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