Will a little change do you good? A putative role of polymorphisms in COVID-19

Adriana Alves Oliveira Paim, Ágata Lopes-Ribeiro,Daniele S.O. Daian e Silva,Luis Adan F. Andrade, Thais F. S Moraes,Edel F. Barbosa-Stancioli,Flávio Guimarães da Fonseca,Jordana G. Coelho-dos-Reis

Immunology Letters（2021）

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摘要

•cytokine-related polymorphisms are paramount for understanding COVID-19.•An entangled Truesome: genetic Polymorphisms, cytokine storm and SARS.•Genes related to innate antiviral immunity are associated with SARS.•interferon receptor IFNAR2 (chr21q22.1; rs2236757) is associated to severe COVID-19.•severe COVID-19 is associated to high expression of TYK2 janus kinase signaling.

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关键词

SARS-CoV-2,Polymorphism,Cytokine storm,SARS

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