Tissue factor promotes airway pathological features through epithelial-mesenchymal transition of bronchial epithelial cells in mice with house dust mite-induced asthma

Junwei Zhao,Tianci Jiang,Pengfei Li,Lingling Dai,Guang Shi,Xiaogang Jing,Shuhui Gao,Liuqun Jia,Shujun Wu,Yu Wang,Youmei Peng,Zhe Cheng

International Immunopharmacology（2021）

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摘要

•High expression of tissue factor (TF) is observed in asthma.•TF downregulation reduce airway pathology in asthmatic mice.•TF downregulation inhibit the EMT of bronchial epithelial cells in asthmatic mice.

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关键词

Asthma,Tissue factor,Airway inflammation,Airway remodelling,Epithelial-mesenchymal transition

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