-866g/A And Ins/Del Polymorphisms In Ucp2 Gene Are Associated With Reduced Short-Term Weight Loss In Patients Who Underwent Roux-En-Y Gastric Bypass

Background: Uncoupling protein 2 (UCP2) plays an important role in energy expenditure regulation. Previous studies have associated the common -8 66G/A (rs659366) and Ins/Del polymorphisms in the UCP2 gene with metabolic and obesity-related phenotypes. However, it is still unclear whether these polymorphisms influence weight loss after bariatric surgery.Objectives: To investigate whether UCP2 -866G/A and Ins/Del polymorphisms are associated with weight loss outcomes after bariatric surgery.Setting: Longitudinal study in a university hospital.Methods: We retrospectively evaluated 186 patients who underwent Roux-en-Y gastric bypass (RYGB) surgery for clinical and laboratory characteristics in the preoperative period, 6, 12, and 18 months after RYGB. The-866G/A (rs659366) polymorphism was genotyped using real-time PCR, while the Ins/Del polymorphism was genotyped by direct separation of PCR products in 2.5% agarose gels.Results: Patients with the-866A/A genotype showed higher body mass index (BMI) after 6, 12, and 18 months of surgery and excess body weight after 6 and 12 months compared with G/G patients. They also showed lower excess weight loss (EWL%) after 6 and 12 months of surgery. Ins allele carriers (Ins/Ins + Ins/Del) had lower delta (D) BMI 12 months after surgery compared with Del/Del patients. Accordingly, patients carrying haplotypes with >2 risk alleles of these polymorphisms had higher BMI and excess weight and lower EWL% during follow-up.Conclusion: UCP2-866A/A genotype is associated with higher BMI and excess weight and lower EWL% during an 18-month follow-up of patients who underwent RYGB, while the Ins allele seems to be associated with lower DBMI 12 months after surgery. Further studies are needed to confirm the associations of the-866G/A and Ins/Del polymorphisms with weight loss after bariatric surgery. (C) 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.