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UV–VIS spectra as potential process analytical technology (PAT) for measuring the density of compressed materials: Evaluation of the CIELAB color space

Tim D. Lillotte, Maike Joester,Benjamin Frindt,Andreas Berghaus, Robert F. Lammens,Karl G. Wagner

International Journal of Pharmaceutics（2021）

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摘要
•Influence of compression on visible (VIS) spectra of pharmaceutical materials.•Density determination via visible (VIS) spectroscopy using CIE color space.•Visible (VIS) spectra as potential process analytical technology (PAT)
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关键词
Process analytical technology (PAT),Color space,Tablet density,Spectrophotometry,Partial least square regression (PLS),Compression,Principal component analysis (PCA)
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