ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.

Aishah Nasir, Alice Cardall,Ramadhan T Othman,Niovi Nicolaou,Anbarasu Lourdusamy,Franziska Linke,David Onion,Marina Ryzhova, Hanna Cameron,Cara Valente,Alison Ritchie,Andrey Korshunov,Stefan M Pfister,Anna M Grabowska,Ian D Kerr,Beth Coyle

Neuro-oncology advances（2021）

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摘要

In this study, we identified a TWIST1-ABCB1 signaling axis during medulloblastoma migration, which can be therapeutically targeted with the clinically approved ABCB1 inhibitor, vardenafil.

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关键词

3D-BME model,ABCB1,Harmine,TWIST1,epithelial–mesenchymal transition,medulloblastoma

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