Semi-Supervised GANs with Complementary Generator Pair for Retinopathy Screening

Several typical types of retinopathy are major causes of blindness. However, early detection of retinopathy is quite not easy since few symptoms are observable in the early stage, attributing to the development of non-mydriatic retinal cameras, these cameras produce high-resolution retinal fundus images that provide the possibility of Computer-Aided-Diagnosis (CAD) via deep learning to assist diagnosing retinopathy. Deep learning algorithms usually rely on a large number of labeled images that are expensive and time-consuming to obtain in the medical imaging area. Moreover, the random distribution of various lesions that often vary greatly in size also brings significant challenges to learn discriminative information from high-resolution fundus images. In this paper, we present generative adversarial networks simultaneously equipped with a “good” generator and a “bad” generator (GBGANs) to make up for the incomplete data distribution given limited fundus images. To improve the generative feasibility of the generator, we introduce a pre-trained feature extractor to acquire condensed features for each fundus image in advance. Experimental results on integrated three public iChallenge datasets show that the proposed GBGANs could fully utilize the available fundus images to identify retinopathy with little label cost.