Partial Agonists Go Molecular

TRENDS IN PHARMACOLOGICAL SCIENCES（2021）

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摘要

Single-channel analysis previously revealed a key role for a shortlived 'flipped' state during glycine receptor activation by partial agonists. Structures solved by Yu and colleagues now reveal a surprising mechanism involving a partially activated agonist-bound closed state that is too long-lived to be considered the flipped state.

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关键词

cryo-electron microscopy,glycine receptors,ligand-gated ion channels,single-channel recording

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