Ball-milling synthesis technique for Cu(II)-Schiff base complexes with variable anions; characterization, potentiometric study and in-vitro assay confirmed by in-silico method

Synthesis of new Cu(II) complexes derived from Schiff base ligand. The new synthesizes were characterized by CHN, IR, 1H NMR, Mass, TGA, EDX, SEM, TEM, XRD, UV-Vis and ESR. The complexes are strictly different due to difference of conjugated anion of original copper salts. Intensive computational studies were carried out by Material Studio, Gaussain09 and Crystal explorer programs. Variable biological applications were performed for all compounds. In-silico assay was also carried out to confirm in-vitro results.