Assessment Of The Granulation Process Effect On Morpho-Anatomical Features And Biologically Active Substances Composition Of Senna Leaves

Cassia senna L. and Cassia angustifolia Vahl. leaves and their preparations are widely acknowledged herbal drugs. Recent development of a novel dosage form - cut-pressed granules - enhances convenience of use in a home setting. However, manufacturing of cut-pressed granules is feasible only if the quality of the material doesn't decrease during granulation. The aim of the study was to assess possible changes in identification parameters and in composition of biologically active substances in Senna leaves after processing. It was shown that TLC chromatographic profiles of herbal drug remain unchanged. Spectrophotometric assessment confirmed that the anthracene aglycones content of the herbal material was also not affected by granulation. It can be concluded that the quality of cut-pressed granules obtained from Senna leaves is not inferior compared to the raw material.