Strategies to overcome resistance to immune checkpoint blockade in lung cancer

Ilaria Attili,Paolo Tarantino,Antonio Passaro,Valeria Stati,Giuseppe Curigliano,Filippo de Marinis

Lung Cancer（2021）

引用 23|浏览2

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摘要

•Resistance to ICIs is mediated by tumor intrinsic and tumor extrinsic mechanisms.•Targeting co-inhibitory or co-stimulatory signals raises antitumour immune response.•Tumour microenvironment conditions the immune infiltrate composition and activity.•Defining an immune profile of tumour, TME and host may help in selecting I–O therapy.

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关键词

Immunotherapy,Resistance mechanisms,Tumour microenvironment,TIGIT,Adoptive cell therapy,Gut microbiota

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