Cobalt Ferrite Decoration of Molybdenum Disulfide Nanosheets; Development of a Nanocomposite-Mediated Hyperthermia Method

The aims were to characterize MoS 2 /CoFe 2 O 4 nanocomposite and investigate its thermal therapy efficiency on cancerous (MCF-7) and normal (MCF-10A) human breast cells. Magnetic nanocomposites (MNCs) characterized by scanning/transmission electron microscopy (SEM/TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and vibrating sample magnetometer (VSM) techniques. TEM and SEM techniques showed MoS 2 /CoFe 2 O 4 MNCs had an average size of 17±4 nm with almost spherical morphology. Magnetic properties of MNC measured by VSM, which resulted in specific loss power (SLP) of 766.61 W/g at 300 K. Cytotoxicity of MoS 2 /CoFe 2 O 4 nanocomposites in MCF-7 and MCF-10A cell lines remained insignificant until 48 hours, which confirms its biocompatibility. Low concentration (200 ug/mL) of MoS 2 /CoFe 2 O 4 was exposed to the low-frequency alternative magnetic field ( f = 150 kHz, H = 31.16 mT) in a way that delivery of thermal ablation via magnetic fluid hyperthermia (MFH) occurred exclusively in cancerous (MCF-7) cells.