P69.05 Molecular and Cellular Heterogeneity Underpin Treatment Response Across a Spectrum of EGFR-Mutant Non-Small Cell Lung Cancer

J. Yuan,E. Lim,S.M. Ma,K.P. Chua, Y.F. Lee, M.J. Lim, X.H. Yeo,C. Phua,A. Takano,Z. Aung,K.H.T. Lim,E. Tan,D. Tan, G.L. Chew,W.L. Tam

Journal of Thoracic Oncology（2021）

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摘要

Non-small cell lung cancer (NSCLC) present a large proportion of intratumoral heterogeneity. The genetic heterogeneity affects key cancer pathways, driving phenotypic variation, and heterogeneous present in environmental parameters that influence cell metabolism, which poses a significant challenge to efficacy of targeted therapies and gaining clinical resistance.

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关键词

Heterogeniety, Progenitor, Drug response

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