Synthesis of Tri-indolylmethane Derivatives Using a Deep Eutectic Solvent

An efficient and facile synthesis of tri-indolylmethane derivatives in a deep eutectic solvent, starting from indoles and indole-3-carbaldehydes, is developed. This methodology offers several advantages, such as simple reaction procedures, use of an inexpensive and a recyclable solvent, and a high yield.