Modelling Of Gas Evolution During Powder Rehydration For Broadband Acoustic Resonance Dissolution Sepectroscopy (Bards)

As a powder wets and dissolves in a liquid, trapped gas bubbles are released and the measurement of the evolution of gas volume versus time can be used to quantify the ease with which powder wets and dissolves in the liquid. This phenomenon forms the basis of the BARDS analytical measurement technique. To complement this experimental approach, a model of the evolution of gas bubbles from a powder into a liquid during powder dispersion and solubilisation is presented. The model is validated against experimental data from the rehydration of Milk Protein Isolate (MPI) powder; both in its original state, and in the agglomerated state and is shown to match the experimental data with good accuracy. Use of the model facilitates a fuller interpretation of the experimental BARDS data and the values of dispersion and solubilisation rate constants can be applied for quantitatively comparing the behaviour of powders. It also permits development of robust rehydration parameters from the experimental BARDS signal.(c) 2021 Elsevier B.V. All rights reserved.