Programmed nanoparticle-loaded microparticles for effective antigen/adjuvant delivery

Rong Xu,Ying Dong,Yajing Zhang,Xiaoli Wang,Chuangnian Zhang,Yanjun Jiang

Particuology（2022）

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摘要

•A microvaccine with SiO2 nanoparticles in CaCO3 microparticles was constructed.•Antigen was conjugated with SiO2, then SiO2 and CpG were co-encapsulated into CaCO3.•Vaccine was internalized via micropinocytosis and improved antigen/adjuvant uptake.•Antigen lysosomal escape was observed, and DCs pulsed by vaccine were fully mature.•The vaccine had good biocompatibility and protected antigens from rapid degradation.

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关键词

Antigen delivery,Cross-presentation,Microparticle,Silica nanoparticle,Bone marrow dendritic cell

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