Modification of Fe 3 O 4 magnetic nanoparticles with a GRGD peptide

Derivatives of RGD peptides are promising vector molecules for targeting biomolecules and nanoparticles into tumor tissues and are used for the design of diagnostic agents. The immobilization of the glutaryl-containing derivative of Gly- l -Arg(Pbf)-Gly- l -Asp(OMe) 2 (GRGD) tetrapeptide on Fe 3 O 4 magnetic nanoparticles (MNPs) was studied. The results of thermogravimetric and elemental analysis, as well as IR spectroscopy, were used to estimate the amount of organic components at each stage of modification of MNPs.