Group-assisted purification chemistry principles to access highly substituted zwitterionic furans via fast, concise, and efficient one-pot three-component assembly
CHEMISTRY OF HETEROCYCLIC COMPOUNDS(2021)
摘要
Novel highly substituted zwitterionic furans were generated through the in situ formation of phosphonium salts. Firstly, intermediate salts were obtained via nucleophilic attack of Huisgen zwitterion to 3-cyanochromones. Finally, these intermediate salts underwent a proton migration, intramolecular cyclization, and ring - opening reaction to convert to the target products. The synthesized furans could be easily purified without traditional purification techniques (chromatography and recrystallization).
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关键词
3-cyanochromones,dialkyl acetylenedicarboxylate,triphenylphosphine,zwitterionic furans,one-pot reaction,three-component reaction
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