JWX-A0108, a positive allosteric modulator of α7 nAChR, attenuates cognitive deficits in APP/PS1 mice by suppressing NF-κB-mediated inflammation

Hui Li, Jie Gao, Yue Chang,Kexin Li,Lei Wang,Chuanxia Ju,Fang Zhang

International Immunopharmacology（2021）

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摘要

•JWX-A0108 improved the spatial memory impairment of APP/PS1 mice.•JWX-A0108 reduced the inflammatory environment of mice brain and protected the hippocampal neurons.•JWX-A0108 reduced the inflammation in APP/PS1 mice brain through NF-κB pathway.

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关键词

α7 nAChRs,Positive allosteric modulator,JWX-A0108,Alzheimer's disease,APP/PS1 transgenic mice,Neuroinflammation

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