Apelin-13 protects human neuroblastoma SH-SY5Y cells against amyloid-beta induced neurotoxicity: Involvement of anti oxidant and anti apoptotic properties.

Mohammad Rasoul Samandari-Bahraseman,Leila Elyasi

Journal of basic and clinical physiology and pharmacology（2022）

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摘要

Apelin-13 prevented apoptosis, oxidative stress, and mitochondrial toxicity and can be a suitable option for treatment of AD. The appropriate treatment strategy for humans has to be investigated in future studies.

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Alzheimer disease,Apelin,Apelin-13 prevented apoptosis, oxidative stress, and mitochondrial toxicity in SH-SY5Y cells that were pretreated with different doses of Apelin (1, 2.5, 5, and 10 μg/mL), half an hour before adding 50% amyloid-β (Aβ) treatment, thus, it can be a suitable option for treatment of AD,neuroprotective agents,oxidative stress

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