A systematic review and meta-analysis of enzyme-linked immunosorbent spot (ELISPOT) assay for BK polyomavirus immune response monitoring after kidney transplantation

•Immune-monitoring for BKV infection in kidney transplant recipient is needed.•This meta-analysis showed that IFN-γ ELISPOT is a potential tool to monitor the immune response against BKV.•Sensitivity, specificity, likelihood ratio, and BKV-specific IFN-γ ELISPOT frequencies are provided.•BKV-specific IFN-γ ELISPOT, together with BK viral load, might guide the immunosuppression adjustment in patients with BKV infection.