Pentoxifylline improves the survival of spermatogenic cells via oxidative stress suppression and upregulation of PI3K/AKT pathway in mouse model of testicular torsion-detorsion

Akanji Omotosho Dhulqarnain,Nasrin Takzaree,Golamreza Hassanzadeh,Heidar Tooli,Mehrnoush Malekzadeh,Nasrin Khanmohammadi,Mahsa Yaghobinejad,Somayeh Solhjoo,Tayebeh Rastegar

Heliyon（2021）

引用 17|浏览8

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摘要

Testicular torsion-detorsion results in enhanced formation of free radicals which contribute to the pathophysiology of testicular tissue damage. Recent reports have identified protective role of pentoxifylline (PTX) against free radicals. Thus, we determined the protective effect of pentoxifylline against testicular damage in mouse model of testicular torsion-detorsion.

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关键词

Pentoxifylline,Testicular torsion-detorsion,Spermatogenesis,Oxidative stress,Antioxidant,PI3K/AKT pathway,Apoptosis

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