Aoiq Catalyzes Geminal Dichlorination Of 1,3-Diketone Natural Products
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY(2021)
摘要
Enzymes that can perform halogenation of aliphatic carbons are of significant interest to the synthetic and biocatalysis communities. Here we describe the characterization of AoiQ, a single-component flavin-dependent halogenase (FDH) that catalyzes gem-dichlorination of 1,3-diketone substrates in the biosynthesis of dichlorodiaporthin. AoiQ represents the first biochemically reconstituted FDH that can halogenate an enolizable sp(3)-hybridized carbon atom.
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