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Potential Kidney Protection with Liraglutide and Semaglutide: Exploratory Mediation Analysis.

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2021)

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摘要
To investigate whether effects on chronic kidney disease risk factors could explain the apparent reduction in kidney outcomes (composite of macroalbuminuria, doubling of serum creatinine, renal replacement therapy, or renal death), primarily driven by changes in albuminuria, after treatment with the glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) liraglutide and semaglutide in patients with type 2 diabetes in the LEADER and SUSTAIN 6 trials.
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关键词
chronic kidney disease,glucagon-like peptide-1 receptor agonist,kidney mediation,liraglutide,semaglutide,type 2 diabetes
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