Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia

Marta Camici,Paolo Zuppi,Patrizia Lorenzini, Liliana Scarnecchia,Carmela Pinnetti,Stefania Cicalini,Emanuele Nicastri,Nicola Petrosillo,Fabrizio Palmieri,Gianpiero D’Offizi,Luisa Marchioni,Roberta Gagliardini,Roberto Baldelli,Vincenzo Schininà,Elisa Pianura,Federica Di Stefano,Stefano Curcio,Lucia Ciavarella,Giuseppe Ippolito,Enrico Girardi

International Journal of Infectious Diseases（2021）

引用 29|浏览14

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摘要

•The prognosis of coronavirus diseases 2019 (COVID-19) is gender-related.•TMPRSS2 plays a key role in COVID-19; androgen receptor regulates its expression.•Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can damage the testes.•Low serum testosterone at diagnosis is predictive of severe COVID-19.•Low serum testosterone predicts for longer hospitalization and hyperinflammation.

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关键词

SARS-CoV-2,Sex hormones,Testosterone,Severity markers,Androgen sensitivity,Gender imbalance

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