Dickkopf-2 knockdown protects against classic macrophage polarization and lipid loading by activation of Wnt/β-catenin signaling

Yuan Zhang,Hongkun Wu,Rui He, Changlun Ye,Hao Chen,Jiao Wang, Zhenggong Li

Journal of Cardiology（2021）

引用 6|浏览2

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摘要

•Dickkopf-2 (Dkk2) expression was upregulated in activated macrophages induced by oxidation low lipoprotein.•Dkk2 silencing alleviated M1 but increased M2 macrophage expression•Dkk2 knockdown promoted translocation of β-catenin expression into the nuclei•Inhibition of β-catenin reversed macrophage activation mediated by Dkk2 silencing

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关键词

Dickkopf-2,Macrophage polarization,Wnt/ β-catenin,Atherosclerosis

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