Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers.

Zoë Rachael Goddard,Andrew Michael Beekman,Marco M D Cominetti,Maria A O'Connell,Isabelle Chambrier,Michael J Cook,María J Marín,David A Russell,Mark Searcey

RSC medicinal chemistry（2020）

引用 10|浏览2

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摘要

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

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