Regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions
Organic & Biomolecular Chemistry(2021)
摘要
An efficient and straightforward metal-free regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide has been described. A series of indolizine-dithiocarbamate derivatives were easily accessed in moderate to good yields with a broad scope. In addition, imidazo[1,2-a]pyridines were also well tolerated to afford diverse imidazoheterocycle-dithiocarbamate products, which are expected to be utilized for drug discovery. Of note, the reaction could be readily scaled up, and shows its practical value in organic synthesis.
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关键词
indolizines,tetraalkylthiuram disulfide,metal-free
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