Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles

•Juvenile chlorpyrifos exposure induced persistent changes in the amygdala proteome.•These changes occurred in proteins related to GABA and glutamate systems.•Similar changes were observed with chlorpyrifos and the FAAH inhibitor PF-04457845.•Inhibition of FAAH by chlorpyrifos leads to alterations in endocannabinoid signaling.•Altered endocannabinoid signaling may be responsible for these persistent changes.