Neurophysiological Correlates of Fatigue in Multiple Sclerosis

Examining fatigue may be beneficial for nurse practitioners to intervene in the care of patients with multiple sclerosis (MS). We measured the relationship of fatigue severity with event-related potentials during electroencephalogram and diffusion basis spectrum imaging/magnetic resonance imaging in 11 participants with relapsing-remitting MS and 5 healthy controls. Data were analyzed to measure brain activity during event-related potentials to responses to cue (correct response) and distractor (incorrect response) using a cognitive performance task. Nurse practitioners caring for patients with MS have an important role in monitoring fatigue severity.