Side Effects And Supportive Care In Relapsed Or Refractory Classical Hodgkin Lymphoma Patients Treated In Later Lines Of Therapy: A Pilot Analysis Conducted In 4 Countries

Introduction: Most patients with classical Hodgkin lymphoma (cHL) can be cured with first-line multiagent chemotherapy. However, up to 20% require second-line (2L) therapy, including autologous hematopoietic cell transplantation (auto-HCT); 50% of those will develop relapsed/refractory cHL (R/R HL) after 2L therapy. The introduction of brentuximab vedotin (BV) in 2011 has changed the management of patients with R/R HL. The European Medicines Agency approved programmed death-1 (PD-1) inhibitor nivolumab (nivo) in 2016 for the treatment of patients with R/R HL who failed auto-HCT and BV and pembrolizumab (pembro) in 2017 for the treatment of R/R HL patients who failed auto-HCT and BV or who are transplant-ineligible and have failed BV. Both agents have improved clinical outcomes for indicated patients. As a pilot analysis, we assessed side effects and supportive care to manage side effects in patients with R/R HL who were treated with BV, nivo, or pembro in third- (3L) or later lines of therapy in real-world practice.