Microwave-Assisted Regioselective Synthesis And 2d-Nmr Studies Of New 1,2,3-Triazole Compounds Derived From Acridone

A simple and mild protocol towards the synthesis of new 1,2,3-triazole compounds derived from acridone has been developed via regiospecific 1,3-dipolar cycloaddition reaction between 10-(prop-2-yn-1-yl)acridone derivatives and aromatic azides using CuI as a catalyst. The cycloaddition reaction has been performed using conventional as well as microwave-assisted methods. Microwave-assisted synthesis caused a significant reduction in the reaction times and improvement in the yields of all the synthesized compounds compared with the conventional method. The structure of the 1,4-disubstituted 1,2,3-triazoles has been elucidated by IR, HRMS, H-1-NMR, C-13-NMR, and 2D NMR (H-1-C-13 HMBC, H-1-H-1 COSY, and H-1-H-1 NOESY) spectroscopies.