Rh(Iii)-Catalyzed Selective C7-H Functionalization Of Indolines With 1,3-Enynes Enables Access To Six-Membered 1,7-Fused Indolines

We described herein a Rh(III)-catalyzed C7-selective C-H activation/annulation of indolines with 1,3-enynes to efficiently access various privileged 1,7-fused indolines bearing an all-carbon quaternary stereogenic carbon center. Notably, the resulting products can be readily transformed into 1,7-fused indoles, further widening the C-7 derivatization of indoles and highlighting the synthetic utility of this methodology. (C) 2021 Elsevier Ltd. All rights reserved.