General Cognition Shows Age-Dependent Patterns of Genetic Overlap With Schizophrenia Liability

Cognition shares substantial genetic overlap with schizophrenia, yet it remains unclear whether such genetic effects increase during developmental periods of elevated risk for schizophrenia, such as the peak age of onset. Should these genetic effects increase around this period, the genetic correlation between cognition and schizophrenia would be expected to differ for individuals who have not yet reached the peak age of onset for schizophrenia compared to those who have reached this age.