Ly6chi Infiltrating Macrophages Promote Cyst Progression in Injured Conditional Ift88 Mice

Ernald Jules G. Aloria,Cheng J. Song,Zhang Li,Mandy J. Croyle,Michal Mrug,Kurt A. Zimmerman,Bradley K. Yoder

Kidney360（2021）

引用 2|浏览9

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摘要

Key Points Ly6chi infiltrating macrophage numbers are increased in injured, conditional Ift88 mice, compared with controls.Loss of Ly6chi infiltrating macrophages slows injury-accelerated cystic disease.Ly6chi infiltrating macrophages drive cystic disease in non-Pkd1–deficient cystic models.

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关键词

cystic kidney disease,basic science,cilia,ciliopathy,infiltrating macrophages,polycystic kidney disease,renal cysts

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