Combination of aztreonam, ceftazidime–avibactam and amikacin in the treatment of VIM-1 Pseudomonas aeruginosa ST235 osteomyelitis

Alessandra Mularoni,Maria Lina Mezzatesta,Michele Pilato,Alice Annalisa Medaglia, Adriana Cervo,Dafne Bongiorno,Ausilia Aprile, Angelo Luca,Stefania Stefani,Paolo Grossi

International Journal of Infectious Diseases（2021）

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摘要

•Metallo-beta-lactamase-producing Pseudomonas aeruginosa osteomyelitis is hard to treat.•Aztreonam/ceftazidime–avibactam combined with amikacin was strongly synergic.•Time-kill curves showed that triple combination achieved 99.9% killing until 48 h.•Antipseudomonal synergistic agents plus debridement resolved the infection.

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关键词

Pseudomonas aeruginosa,ST235,VIM-1,Ceftazidime–avibactam,Aztreonam,Osteomyelitis

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