Paired dCas9 design as a nucleic acid detection platform for pathogenic strains

Yihao Zhang,Yu Wang,Luze Xu,Chunbo Lou,Qi Ouyang,Long Qian

Methods（2022）

引用 9|浏览17

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摘要

•Split luciferase-dCas9 enables sensitive detection of targeted DNA sequences.•The system’s programmability reveals design principles for microbial DNA detection.•An array-based assay robustly detects pathogen DNA by combinatorial statistics.•The system presents a prototype for facile and reliable point-of-care diagnostics.

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关键词

Nucleic acid detection,dCas9,Biosensor,Molecular Diagnostics

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