Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared and Raman spectroscopy

Edina Szabó,Petra Záhonyi,Martin Gyürkés,Brigitta Nagy,Dorián L Galata,Lajos Madarász,Edit Hirsch,Attila Farkas,Sune K Andersen,Tamás Vígh,Geert Verreck,István Csontos,György Marosi,Zsombor K Nagy

European Journal of Pharmaceutical Sciences（2021）

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摘要

•Continuous feeding, blending and tableting of electrospun fibers was accomplished.•In-line monitoring of the amorphous solid dispersion content was performed.•The prepared tablets passed the USP <905> content uniformity test.•Continuous manufacturing of milled electrospun materials to tablets proved feasible.

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关键词

Amorphous solid dispersion,Electrospinning,Scale-up,Continuous formulation,Process analytical technologies,Tablets

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