Clinical correlates of white matter lesions in Parkinson's disease using automated multi-modal segmentation measures

Eric Fang,Mário João Fartaria,Chu Ning Ann,Bénédicte Maréchal,Tobias Kober,Jie Xin Lim,Leon Qi Rong Ooi,Celeste Chen,Soo Lee Lim,Eng King Tan,Ling Ling Chan

Journal of the Neurological Sciences（2021）

引用 4|浏览11

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摘要

•White matter lesions (WML) are common co-morbidities in Parkinson's disease (PD)•Periventricular WML significantly predicted UPDRS-III motor scores in PD•Frontal WML predicted cognitive impairment and frontal lobe dysfunction in PD•Automated segmentation algorithms quantify WML, facilitating precision medicine•Regional WML quantification may aid domain-specific clinical assessment in PD

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关键词

Parkinson's disease,Diagnostic imaging,Automation,Leukoaraiosis,Biomarkers

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