Insights from a laboratory and naturalistic investigation on stress, rumination and frontal brain functioning in MDD: An fNIRS study

David Rosenbaum,Isabell Int-Veen,Hendrik Laicher,Florian Torka,Agnes Kroczek,Julian Rubel,Glenn Lawyer,Zoé Bürger,Isabel Bihlmaier,Helena Storchak,Kerstin Velten-Schurian,Thomas Dresler,Ramona Täglich,Betti Schopp,Hans-Christoph Nürk,Birgit Derntl,Vanessa Nieratschker,Andreas J Fallgatter,Ann-Christine Ehlis

Neurobiology of Stress（2021）

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摘要

Recent research has emphasized rumination as an important maintaining factor in various mental disorders. However, operationalization and therefore induction of rumination in experimental settings poses a major challenge in terms of ecological validity. As stress seems to play a key role in everyday situations eliciting rumination, we conducted two stress paradigms while assessing behavioral and neurophysiological measures.

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关键词

Rumination,Trier Social Stress Test (TSST),Socially Evaluated Cold-Pressor Test (SECPT),functional near-infrared spectroscopy (fNIRS),Repetitive negative thought,Major Depressive Disorder

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