Comprehensive investigation of the tumor microenvironment (TME) in Head and Neck Squamous cell carcinoma (HNSCC) using single cell RNA sequencing

C Kürten,X Chen,A Kulkarni,X Lu,RL Ferris,S Lang

Abstract- und Posterband – 90 Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie eV, Bonn – Digitalisierung in der HNO-HeilkundeLaryngo-Rhino-Otologie（2019）

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摘要

Immunotherapy has significantly advanced HNSCC treatment, however the response rate is only 15 – 20% due to factors in the TME formed by stroma, cancer and immune cells. Studying heterogeneous cell populations is greatly facilitated by the recent development of single-cell RNA sequencing, a technique that can be leveraged to investigate the transcriptomic composition of individual cells to determine their origin as well as current functional state.

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关键词

Head and neck squamous-cell carcinoma,Tumor microenvironment,Cell,RNA,Cancer research,Medicine

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