Personalized medicine modality based on patient-derived xenografts from a malignant transformed GCTB harboring H3F3A G34W mutation

Jiang Yafei,Mu Haoran,Jiang Wenyan,Xue Linghang,Tian Kai,Wang Gangyang,Wang Zhuoying,Han Jing,Yang Mengkai,Tang Yujie,Hua Yingqi,Cai Zhengdong

Journal of Orthopaedic Translation（2021）

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摘要

•PDX model were established from a malignant GCTB patient.•PDCs and PDX maintained same oncohiston mutations as those in the original patient.•ITF-2357 inhibits malignant GCTB progression in vitro and in vivo.

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关键词

Malignant giant cell tumor of bone,Drug screening,Patient-derived xenograft,Histone deacetylase inhibitor

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