Multi-component Bioresponsive Nanoparticles for Synchronous Delivery of Docetaxel and TUBB3 Sirna to Lung Cancer Cells.

Claudia Conte,Patricia F. Monteiro,Pratik Gurnani,Snow Stolnik,Francesca Ungaro,Fabiana Quaglia,Philip Clarke,Anna Grabowska,Maria Kavallaris,Cameron Alexander

Nanoscale（2021）

引用 28|浏览17

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摘要

Redox-responsive NPs, delivering DTX in combination with TUBB3 siRNA, increased DTX activity in lung cancer (LC) cells. After local administration in LC mice models, NPs were retained into the lungs thus exerting high siRNA silencing efficacy.

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