Piceatannol protects against sepsis-induced myocardial dysfunction via direct inhibition of JAK2

Lingpeng Xie,Yuting Wu, Chuying Zhou,Zhangbin Tan,Honglin Xu,Guanghong Chen,Hongmei Chen,Guiqiong Huang,Huijie Fan,Lei Gao,Bin Liu,Yingchun Zhou

International Immunopharmacology（2021）

引用 9|浏览10

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摘要

•Piceatannol exerts protective effect against sepsis-induced myocardial dysfunction.•Piceatannol treatment attenuated myocardial damage and inflammation caused by sepsis.•Piceatannol has a strong binding affinity to JAK2 protein.•Piceatannol inhibited the activation of the JAK2/STAT3 signaling.

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关键词

Piceatannol,JAK2,Sepsis-induced myocardial dysfunction,Inflammation,Apoptosis

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