Poor Antibody Response After Two Doses of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine in Transplant Recipients

Alessandra Mazzola,Eve Todesco,Sarah Drouin,Fanny Hazan,Stéphane Marot,Dominique Thabut,Shaida Varnous,Cathia Soulié,Benoît Barrou,Anne-Geneviève Marcelin,Filomena Conti

CLINICAL INFECTIOUS DISEASES（2022）

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摘要

A low anti-spike antibody response of 28.6% was observed 28 days after BNT162b2 vaccine second dose among 133 solid organ transplant recipients without previous coronavirus disease 2019 (COVID-19). No serious adverse events were recorded. Four severe COVID-19 cases were reported between or after the 2 doses. Our data suggest to change the vaccine strategy.

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SARS-CoV-2 vaccination, SOT recipients, humoral response, COVID-19 disease, anti-spike antibodies

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