Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study

•We validated the use of corticosteroids for patients with severe alcohol-associated hepatitis defined by an MELD score >20.•The use of corticosteroids was associated with increased 30-day survival.•The maximum benefit of corticosteroids was seen in patients with MELD scores between 25-39.•A MELD score >51 can be used to define futility of corticosteroid treatment in patients with severe AH.•The survival benefit was not sustained at 90 or 180 days.